Company Announcements

ONDINE BIOMEDICAL INC.

("Ondine Biomedical", "Ondine" or the "Company")

Ondine continues commercial growth

Ondine Biomedical Inc. (LON: OBI), the Canadian life sciences company pioneering light-activated antimicrobial treatments, announces that it has made significant progress with the commercial roll-out of its novel nasal decolonization technology, Steriwave^®, in both Canada and the UK. Steriwave is a simple 5-minute procedure that reduces healthcare-associated infections (HAIs) by rapidly decolonizing the nose without the use of antibiotics or generating antimicrobial resistance (AMR).

In the UK, two of the largest NHS Trusts, King's College Hospital NHS Trust and Leeds Teaching Hospitals NHS Trust, are initiating Steriwave treatment prior to surgery. Recently Ondine announced that has partnered with Mölnlycke Health Care, a world-leading MedTech company that specializes in innovative solutions for wound care and surgical procedures, to bring Ondine's Steriwave® nasal decolonization technology to the United Kingdom, EU, and Middle East markets.

In Canada, Steriwave is being used routinely in five (half) of the country's top 10 largest hospitals: Royal Alexandra (Alberta), The Ottawa Hospital - Civic Campus (Ontario), Vancouver General (BC), University of Alberta Hospital, and the Queen Elizabeth II Hospital (Nova Scotia).[1] In the last few months, five additional Canadian healthcare facilities have started using Steriwave to decolonize patients undergoing orthopedic surgery. These include University Hospital of Northern British Columbia, Royal Inland Hospital, Eagle Ridge Hospital, Okanagan Health Surgery Centre, and Hawkesbury General Hospital.

Steriwave is also being used in all five of British Columbia's Health Authorities and benefitting from expanding regional adoption. For example, Royal Inland is the fourth hospital in Canada's British Columbia Interior Health Authority to adopt Steriwave alongside Kelowna General, Penticton Regional, and Kootenay Boundary. Eagle Ridge Hospital became the third hospital to embrace Steriwave in the Fraser Health Authority, following Burnaby Hospital, one of the largest hospitals outside the city of Vancouver and the Royal Columbian Hospital, which will be the first hospital to trial Steriwave to prevent infections in ICUs. The four major hospitals in the Vancouver Coastal Health Authority - the first to adopt nasal photodisinfection - have deployed Steriwave in their presurgical infection prevention protocols.

Nicole Walby, Clinical Operations Manager at Interior Health Authority, commented:

"Steriwave has been fully embraced by patients and staff alike, with patients and their families feeling reassured by the added protection. It's made a noticeable difference at our facility, bringing a sense of ease and comfort to an otherwise serious environment. Preventing surgical site infection through important tools such as Steriwave is a top priority for our clinicians in upholding and improving patient experiences."

One in nine hospital patients in Canada gets an HAI resulting in approximately 12,000 deaths a year.[2] HAIs are also becoming harder to treat due to rising rates of AMR which are making some commonly used antibiotics ineffective.[3] This has meant that one in 19 deaths in Canada is now attributable to antibiotic-resistant infections.[4] The cost of AMR to the Canadian healthcare sector is also projected to increase from $1.4 billion to $7.6 billion per year by 2050.^[5]

Steriwave is a novel antimicrobial treatment that uses a proprietary light-activated agent to decolonize the nose and rapidly eliminate infection-causing pathogens. The agent is applied to each nostril using a nasal swab and then illuminated with a specific wavelength of red light. The light activates the photodynamic agent, causing an oxidative burst that destroys infection-causing bacteria, viruses and fungi in a single, 5-minute treatment. The process works so rapidly that pathogens do not have the opportunity to develop resistance, making it a viable alternative to antibiotics.

About Ondine Biomedical Inc.

Ondine Biomedical Inc. is a Canadian life sciences company and leader in light-activated antimicrobial therapies (also known as 'photodisinfection'). Ondine has a pipeline of investigational products, based on its proprietary photodisinfection technology, in various stages of development.

Ondine's nasal photodisinfection system has a CE mark in Europe and is approved in Canada and several other countries under the name Steriwave^®. In the US, it has been granted Qualified Infectious Disease Product designation and Fast Track status by the FDA and is currently undergoing clinical trials for regulatory approval. Products beyond nasal photodisinfection include therapies for a variety of medical indications such as chronic sinusitis, ventilator-associated pneumonia, burns and other indications.

About Steriwave

Steriwave is a groundbreaking antimicrobial treatment that uses a light-activated antimicrobial agent to rapidly eliminate a broad spectrum of pathogens, including bacteria, viruses, and fungi. The treatment is administered in a simple two-step process: first, the agent is applied to each nostril with a nasal swab, followed by illumination with a specific wavelength of red light. The light activates the agent, causing an oxidative burst that destroys pathogens within the single 5-minute treatment, offering a robust alternative to traditional antibiotics without the risk of developing resistance.

Nasal decolonization is recommended in the 2016 WHO Global guidelines for the prevention of surgical site infections,[6] and the Society for Healthcare Epidemiology of America (SHEA) guidelines, published in May 2023, recommend nasal decolonization for major surgical procedures.[7]

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